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UCSC Stem Cell Journal Club
A journal club for the UCSC CIRM training program—open to anyone interested in stem cell research.
123 Sinsheimer Labs
UC Santa Cruz
3:00-5:00 pm
Refreshments served
Spring 2008 program:
April 7
Presenter: Courtney Onodera
Paper: Stadtfeld M, Maherali N, Breault DT, Hochedlinger K. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 6 March 2008; 2:230-40.
Figure presenters: Courtney Onodera (figures 1&7), Megan Hall (figure 2), Martina Koeva (figure 3), Martin Hudson (figure 4), Kristel Dorighi (figure 5), Anne Royou (figure 6)
May 5
Presenter: Kristel Dorighi
Paper: Sinkkonen L, Hugenschmidt T, Berninger P, Gaidatzis D, Mohn F, Artus-Revel CG, Zavolan M, Svoboda P, Filipowicz W. MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat Struct Mol Biol. 2 Mar 2008;15(3):259-67.
Figure presenters: Martina Koeva (figure 1), Courtney Onodera (figure 2), Megan Hall (figure 3), Dave Feldheim (figure 4), Martin Hudson (figure 5), Kristel Dorighi (figure 6)
June 2
Presenter: Martina Koeva
Paper: Wong DJ, Lui H, Ridky TW, Cassarino D, Segal E, Chang HY. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell. 10 April 2008; 2(4):333-44.
Figure presenters: Courtney Onodera (figure 1), Anne Royou (figure 2), Kristel Dorighi (figure 3), Megan Hall (figure 4), Martin Hudson (figure 5), Jake Kirkland School (figure 6)
Winter 2008 program:
January 14
Presenter: Anne Royou
Paper: McDermott KM, Zhang J, Holst CR, Kozakiewicz BK, Singla V, Tlsty TD. p16INK4a prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biology. 14 Februay 2006; 4(3): e51.
Figure presenters: Anne Royou (intro and figure 1), Kristel Dorighi (figure 2) Martina Koeva (figures 3, 8a&b), Courtney Onodera (figures 4,8c&d), Sofie Salama (figure 5), Dave Feldheim or Anne (figure 6), Sol Katzman or Kristel (figure 7)
February 11
Presenter: Megan Hall
Paper: Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 30 November 2007; 131:861-72.
Figure presenters: Megan Hall (intro and figure 1), Courtney Onodera (figure 2) Martina Koeva (figure 3), Kristel Dorighi (figures 4 & 5), Anne Royou (figure 6 & suppl movie S1), Martin Hudson (figure 7 & suppl figures 3A & B)
Additional paper for brief discussion: Yu J et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 21 December 2007; 318(5858):1917-20.
March 10
Presenter: Martin Hudson
Paper #1: Andäng M et al. Histone H2AX-dependent GABAA receptor regulation of stem cell proliferation.Nature. 24 January 2008; 451:460-4.
Figure presenters: Martin Hudson (intro and figure 1a-e), Martina Koeva (figure 1 f-j), Jake Kirkland School (figure 2 a-f), Courtney Onodera (figure 2 g-j), Anne Royou (figure 3 a-i), Dave Greenberg ( figure 3 j-o), Armen Shamamian (figure 4 a-d), Megan Hall (figure 4 e-j)
Paper #2: Cavallaro M et al. Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants. Development. 2008; 135:541-57.
Figure presenters: Martin Hudson (figures 1&2), Martina Koeva (figures 3&4), Anne Royou (figures 5&6), Dave Greenberg (figures 7&8), Megan Hall (figure 9), Courtney Onodera (figures 10&11), Jake Kirkland School (figure 12)
Fall 2007 program:
October 1—123 Sinsheimer Labs
Presenter: Courtney Onodera
Paper:Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S. Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature. 2007 Sep 20;449(7160):346-50.
Figure presenters: Dave Feldheim (figure 1), Kristel Dorighi (figure 2), Martina Koeva (figure 3), Megan Hall (figure 4, supp figure 1)
November 5—533 Engineering 2
Presenter: Kristel Dorighi
Paper: Jude CD, Climer L, Xu D, Artinger E, Fisher JK, Ernst P. Unique and independent roles of MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell. 2007 Sept 13;1(3):324-37.
Figure presenters: Megan Hall (figure 1), Martina Koeva (figures 2 and 3), Courtney Onodera (figure 4), Anne Royou (figure 5), Hema Vayadanathan (figure 6), Kristel Dorighi (figure 7)
December 3—123 Sinsheimer Labs
Presenter: Martina Koeva
Paper: Czechowicz A, Kraft D, Weissman IL, Bhattacharya D. Efficient transplantation via antibody-based clearance of
hematopoietic stem cell niches. Science. 2007 November 23;318(5854):1296-9.
Figure presenters: Anne Royou (figure 1), Courtney Onodera (figure 2), Kristel Dorighi (figure 3), Megan Hall (figure 4)
Spring 2007 program:
April 23
Presenter: Roland Nagel
Paper: Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, Ling EK, Ward RJ, Jamieson LG, Tyers M, Dirks PB. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007 Apr 8; [Epub ahead of print].
Figure presenters: Hema Vayadanathan, Martina Koeva, Roland Nagel (figure 1, supp figure 1, supp figure2, supp figure3)
Will McKenna, Courtney Onodera, Karen Artiles (figure 2, supp table 1, supp table 2)
Stephanie McClymont, Samir Patel, Gayatri Pal (figure 3 , supp table 3, supp table 4)
David Feldheim, Armen Shamamian (figure 4, supplemental methods)
Supplements: http://www.nature.com/nchembio/journal/v3/n5/suppinfo/nchembio873_S1.html
May 14:
Presenter: Anne Royou (2 papers)
Paper #1: Yamashita YM, Mahowald AP, Perlin JR, Fuller MT. Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Science. 2007 Jan 26; 315(5811):518-21.
Figure presenters: Hema Vayadanathan (figure 1), Dave Feldheim (figure 2), Roland Nagel (figure 3), Will McKenna (figure 4), Anne Royou (supp figure 1)
Paper #2: Rebollo E, Sampaio P, Januschke J, Llamazares S, Varmark H, González C. Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing drosophila neural stem cells. Developmental Cell. 2007 March; 12:467-74.
Figure presenters: Courtney Onodera (figure 1), Martina Koeva (figure 2), Stephanie McClymont (figure 3), Armen Shamamian (figure 4), Anne Royou (supp figures 1 and 2)
June 18:
Presenter: Will McKenna
Paper:Maherali N, Sridharan R, Xie W, Utikal J, Eminli S, Arnold K, Stadtfeld M, Yachechko R, Tchieu J, Jaenisch R, Plath K, Hochedliner K. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell. 2007 Jun 7; 1:55-70.
Figure presenters: Will McKenna (figure 1), Martina Koeva (figure 2), Courtney Onodera (figure 3), Martina Koeva (figure 4), Hema Vayadanathan (figure 5), Dave Feldheim (figure 6), Anne Royou (figure 7), group (figure 8)
Winter 2007 program:
January 29
Presenter: Hema Vaidyanathan
Paper: De Coppi P, Bartsch G Jr, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S, Atala A. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007 Jan;25(1):100-6. Epub 2007 Jan 7.
February 26
Presenters: Martina Koeva and Courtney Onodera
Paper: Regulation of apoptosis and differentiation by p53 in human embryonic stem cells. J Biol Chem. 2007 Feb 23;282(8):5842-52. Epub 2006 Dec 19.
March 26
Presenter: Will McKenna
Papers:
Simon A, Frisén J. From stem cell to progenitor and back again. Cell, 9 March 2007; 128(5):825-826.
Nakagawa T, Nabeshima Y, Yoshida S. Functional identification of the actual and potential stem cell compartments in mouse spermatogenesis. Developmental Cell. February 2007; 12(2):195-206.
Figure presenters: 1. Anne Royou; 2. Stephanie McClymont; 3. David Feldheim; 4. Will McKenna; 5. Martina Koeva; 6. Hema Vayadanathan; 7. Roland Nagel
Fall 2006 program:
October 20, 2006
Presenters: Kristel Dorighi and Stephanie McClymont
Topic: Epigenetics of stem cells
Papers: http://www.nature.com/nature/journal/v441/n7091/abs/nature04733.html
http://www.nature.com/nature/journal/v423/n6937/abs/nature01587.html
November 3, 2006
Presenters: Martina Koeva and Courtney Onodera
Topics: Stem cell division is regulated by the microRNA pathway: http://www.nature.com/nature/journal/v435/n7044/full/nature03816.html
A microRNA polycistron as a potential human oncogene: http://www.nature.com/nature/journal/v435/n7043/full/nature03552.html
December 1, 2006
Presenters: Hema Vaidyanathan and Will McKenna
Topic: Biology and therapeutic uses of neural stem cells
Papers: Androutsellis-Theotokis A et al. Notch signalling regulates stem cell numbers in vitro and in vivo. Nature. 2006 Aug 17;442(7104):823-6.
Roy NS et al. Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nature Medicine. 2006 12:1259-68.
Sponsors:
UCSC CIRM Training Program in Systems Biology of Stem Cells
California Institute for Quantitative Biosciences (QB3)
Millipore
Peggy Farnham
Associate Director of Genomics, Genome Center, UC Davis School of Medicine
Using ChIP-chip and ChIP-seq technology to characterize
mechanisms of transcriptional repression
Monday, June 2, 2008, 12:30–1:30 pm
Natural Sciences Annex 101
Hosts: Camilla Forsberg & Susan Strome
Kismet: a drosophila chromatin-remodeling factor with
roles in transcription and development
Kristel Dorighi, UCSC Stem Cell Scholar, MCD Biology, Tamkun Lab
3rd Year Talk
Friday, April 25, 2008, 12:30–1:30 pm
Natural Sciences Annex 101
Kaiming Ye
Assistant Professor, Biomedical Engineering, College of Engineering, University of Arkansas
Toward cell therapy for diabetes—directing the differentiation of
embryonic stem cells into mature insulin-producing beta cells in 3D
cultures
Tuesday, April 15, 2008, 12:00 pm
Engineering 2 Building, room 599
 More information
Host: Dietlind Gerloff, Biomolecular Engineering
Nate Dudley
UC Santa Barbara, MCD Biology
Investigating the molecular mechanisms of totipotency in the C. elegans germline
Friday, April 11, 2008, 12:30–1:30 pm
Natural Sciences Annex 101
Host: Susan Strome, MCD Biology
Arturo Alvarez-Buylla
Department of Neurological Surgery, UCSF
March 10, 2008, 12:30–1:30 pm
Natural Sciences Annex 101
Yibing Qyang
Research fellow in medicine, Massachusetts General Hospital, Harvard Medical School, Harvard Stem Cell Institute
High-throughput chemical screening implicates the Wnt/ß-catenin pathway in the renewal and differentiation of Isl1+ cardiovascular progenitors
February 28, 2008, 12:30–1:30 pm
240 Physical Sciences
Tony De Tomaso
Department of Pathology, Stanford School of Medicine
Transplantation, regeneration, and parasitic stem cells: the strange life of a basal chordate
February 12, 2008, 12:00 pm
305 Physical Sciences
Host: Todd Lowe
Seminar: Evolution and specification of mammalian germ layers
Julie Baker, Stanford University
Monday, November 19, 12:30–1:30 pm
101 Natural Sciences Annex
UC Santa Cruz
Host: David Feldheim
Bioethicist Jonathan Moreno
Jonathan Moreno is an elected member of the Institute of Medicine (IOM) of the National Academies and has been a member of numerous National Academies committees. He co-chaired the Committee on Guidelines for Human Embryonic Stem Cell Research, has served as a senior staff member for two presidential advisory committees, and has given invited testimony for both houses of congress. He is a past president of the American Society for Bioethics and Humanities and an advisor to the Howard Hughes Medical Institute, the Bill and Melinda Gates Foundation, and GlaxoSmithKline. He is also a Faculty Affiliate of the Kennedy Institute of Ethics at Georgetown University and a Fellow of the Hastings Center and the New York Academy of Medicine. Moreno has published more than 250 papers, reviews, and book chapters and is a member of several editorial boards. He is a frequent guest on news and information programs.
October 29–31, 2007
The ethics of human embryonic stem cell research
Monday, October 29, 12:30–1:30 pm
101 Natural Sciences Annex
An introduction to the science of embryonic stem cells, followed by a discussion of the ethical and policy issues. Key ethical issues include the sources of human embryonic stem cells, egg donation, and chimeras. Policy issues stem from the National Academies of Science 2005 Guidelines on Stem Cell Research; Moreno co-chaired the committee developing these guidelines.
The ethics of human experimentation for national security purposes
Monday, October 29, 5:00–6:30 pm
Stevenson College Fireside Lounge
This talk, offered by the Philosophy Department, will be open to the campus as a whole.
Mind wars: brain research and national defense
Tuesday, October 30, 2:00–3:45 pm
Stevenson College Event Center
Based on his new book of the same title, Moreno will explore the past, present, and future of national security agency interest in the brain and examine the ethical and social questions raised by an increasingly powerful set of tools in neuroscience.
Ethical issues in the lab and publication
Wednesday, October 31, 10:00 am–12:00 pm
123 Sinsheimer Labs
Moreno will lead a discussion of lab and publication ethics in conjunction with the Introduction to Stem Cell
Biology class.
Seminar—Gary Felsenfeld: Chromatin boundaries and epigenetic regulation of gene expression
Save the date for this seminar with Gary Felsenfeld, chief of the Physical Chemistry Section of the National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK), National Institutes of Health. Felsenfeld studies the relationship between chromatin structure and gene expression in eukaryotes, with particular interest in epigenetic regulation of globin gene expression as a model system.
Monday, June 4, 2007
12:30 pm
Natural Sciences Annex 101
UC Santa Cruz
Sponsored by the UCSC CIRM Training Program in Systems Biology of Stem Cells
Stem cells & justice: Joe Tayag
Joe Tayag, health program manager for the Greenlining Institute, will discuss his organization's efforts to get issues of social justice on California's stem cell agenda.
May 30, 2007
Time and place TBA
Sponosored by the Science & Justice Working Group
Bay Area Stem Cell Club
The Bay Area Stem Cell Club promotes interactions, collaborations, and scientific exchange among stem cell scientists in the Bay Area. Participation is open to all interested parties, but only students and post-docs present their work.
Focus: Hematopoietic stem cells
 Program and directions
May 7, 2007
4:00-6:00 pm, scientific program
6:00-7:00 pm, social hour, drinks and appetizers
Stanford University, location TBA
RSVP: Erica Stidham, stidhame@stemcell.ucsf.edu
Bay Area Stem Cell Club
The Bay Area Stem Cell Club promotes interactions, collaborations, and scientific exchange among stem cell scientists in the Bay Area. Participation is open to all interested parties, but only students and post-docs present their work.
March 15, 2007
4:00-6:00 pm, scientific program
6:00-7:00 pm, social hour, drinks and appetizers
UCSF Mission Bay Campus
Genentec Hall Auditorium, 1st floor
1600 16th Street
San Francisco
Presentations:
"An RNAi screen reveals the chromatin remodeling factor Chd1 as a new regulator of ES cells," Alex Gaspar Maia, Ramalho-Santos Lab, UCSF
"Transcriptional regulation of Nanog by Oct4 and Sox2," Yick Fong, Ph.D., Tijan Lab, UC Berkeley
"Derivation of hESCS in xeno-free conditions" Eric Chiao, Ph.D., Baker Lab, Stanford
"Polarity and pluripotency," Ana Krtolica, Ph.D., Fisher Lab, UCSF
RSVP: Erica Stidham, stidhame@stemcell.ucsf.edu
Directions and parking information: http://pub.ucsf.edu/missionbay/directions/
Sponsor: Genentech
Seminar—Arnold Kriegstein: Neural stem and progenitor cells in cortical development
Arnold Kriegstein directs the Program in Developmental and Stem Cell Biology and professor of neurology at the University of California, San Francisco. Kriegstein studies neocortical development, neural differentiation, and development.
Monday, March 5, 2007
12:30 pm
Natural Sciences Annex 101
UC Santa Cruz
Sponsored by the UCSC CIRM Training Program in Systems Biology of Stem Cells
Frontiers of stem cell biology, 25th Anniversary Celebration
The UCSF Institute for Regeneration Medicine invites you to an international symposium to explore the frontier of stem cell science and celebrate the 25th anniversary of the co-discovery of embryonic stem cells by UCSF professor Gail Martin. The symposium will include presentations, discussions, a round table panel, and an opportunity to establish collaborative projects for researchers, students, and industry representatives from California and around the world. Featured presentations will include stem cell and tissue regeneration research discoveries in disease-related areas including cancer, heart disease, diabetes, and traumatic and degenerative nervous system diseases such as Parkinson’s disease. Additional presentations will provide an overview of the potential and reality of cell and tissue based regeneration therapies.
Wednesday, November 29, 2006
9:00 am–6:00pm
Mission Bay Conference Center
UC San Francisco
Guest Speakers:
Austin Smith, University of Cambridge, UK
Gordon Keller, Mount Sinai School of Medicine
Laurie Zoloth, Northwestern University, IL
Gail Martin, UCSF
Jane Lebkowski, Geron Corp.
and experts from UCSF in cancer, neural, cardiac, and pancreatic stem cells, including scientists working with human embryonic stem cells.
Seminar: Michael D. West,
Human embryonic stem cell lines derived from single blastomeres
Michael D. West is President and Chief Scientific Officer of Advanced Cell Technology and is Adjunct Professor of Bioengineering at the University of California, Berkeley. Dr. West has extensive academic and business experience in age-related degenerative diseases, telomerase molecular biology and human embryonic stem cell research and development.
November 27, 2006, 2:00 pm
123 Sinsheimer Labs
UC Santa Cruz
Bay Area Stem Cell Club:
Neural stem cells
The Bay Area Stem Cell Club promotes interactions, collaborations, and scientific exchange among stem cell scientists in the Bay Area. Participation is open to all interested parties, but only students and post-docs present their work.
July 19, 2006
4:00-6:00 pm, scientific program
6:00-7:00 pm, social hour
Fisher Banquet Room, Mission Bay Community Center, UCSF
Presentations:
Welcome, Arnold Kriegstein, M.D., Ph.D., Director, UCSF Institute for Regenerative Medicine
"Neural stem cells on the move—relocation of neural stem cells in the developing dentate gyrus," Grant Li, Ph.D., Pleasure Lab, UCSF
"Absence of MCP-1 protects neurogenesis from cranial irradiation," Star Lee, Palmer Lab, Stanford University
"Patterns of cellular genesis during embryonic cortical development," Stephen Noctor, Ph.D., Kriegstein Lab, UCSF
RSVP: Erica Stidham, stidhame@stemcell.ucsf.edu
Directions and parking information: http://pub.ucsf.edu/missionbay/directions/
Sponsor: Genentech
The scientific challenge: from basic science to the clinic
This meeting, a part of the CIRM scientific strategic planning process, will review different models of developing discoveries into therapies.
Speakers:
Stuart Orkin, M.D.—Harvard Medical School
Joan Samuelson, Esq.—Parkinson’s Action Network
Allen M. Spiegel, M.D.—Albert Einstein College of Medicine
Jill Heemskerk, Ph.D.—National Institute of Neurological Disorders and Stroke
Stephen A. Sherwin, M.D.—Cell Genesys, Inc.
July 13, 2006
10:00 am–4:00 pm
J. David Gladstone Institutes
Robert W. Mahley Auditorium
1650 Owens Street, San Francisco, CA 94158
For more information please contact Kate Shreve at 415-396-9118 or kshreve@cirm.ca.gov
http://www.cirm.ca.gov/strat/pdf/071306_conf.pdf
5th Annual Robert L Sinsheimer Distinguished Lecture: Irving L. Weissman
Stem cells: units in regeneration, cancer, & natural selection
Watch it on UC TV
Irving L. Weissman is Professor of Pathology and Developmental Biology and Director of the Institute for Stem Cell Biology and Regenerative Medicine at the Stanford University School of Medicine
May 11, 2006, 4:30 pm
Media Theater
UC Santa Cruz
This event is open to the public
Click for map
Sponsors:
UCSC Department of Molecular, Cell, and Developmental Biology Department
California Institute for Quantitative Biomedical Research (QB3)
Bay Area Stem Cell Club
inaugural meeting: Cancer stem cells
The Bay Area Stem Cell Club arose from a smaller group of Stanford and UCSF scientists. It promotes interactions, collaborations, and scientific exchange among stem cell scientists in the Bay Area. Participation is open to all interested parties, but only students and post-docs will be allowed to present their work. At the inaugural meeting, the group will discuss topics and solicit volunteer presenters for future meetings.
May 3, 2006
4:00-6:00 pm, scientific program
6:00-7:00 pm, social hour
Fisher Banquet Room, Mission Bay Community Center, UCSF
Presentations:
Welcome, Arnold Kriegstein, M.D., Ph.D., Director, UCSF Institute of Stem Cell & Tissue Biology
"Cancer stem cells in head and neck squamous cell carcinoma," Laurie Ailles, Ph.D., Weissman Lab, Stanford University
"Investigating the role of PDGF signaling in adult neural stem cells & brain tumor initiation," Erica Jackson, Ph.D., Alvarez-Buylla Lab, UCSF
RSVP: Erica Stidham, stidhame@stemcell.ucsf.edu
Directions and parking information: http://pub.ucsf.edu/missionbay/directions/
Sponsor: Genentech
Forum on stem cell ethics: Laurie Zoloth
Laurie Zoloth is Professor of Medical Ethics and Humanities and of Religion at Northwestern University. She directs the Center for Bioethics, Science, and Society at Northwestern’s Feinberg School of Medicine. Among numerous other affiliations, Professor Zoloth is on the Executive Committee of the International
Society for Stem Cell Research and serves as the Chair of the Howard Hughes Medical Institute's Bioethics Advisory Board.
Read about this event in the Santa Cruz Sentinel
May we make the world? Bioethics, stem cells, and the new biology
Watch a video of this program
Introductions by UCSC professors
Ellen Suckiel, Philosophy
and Manuel Ares Jr. , Molecular, Cell, and Developmental Biology
April 17, 2006, 4:00 pm
Stevenson College Event Center
UC Santa Cruz
This event is open to the public
Must we always tell the truth? Integrity in science
This talk, aimed at scientists and science students, is a part of the MCD Biology Spring 2006 Seminar Series. Hosted by Manuel Ares Jr. , Molecular, Cell, and Developmental Biology
April 17, 2006, 12:30 pm
Engineering Auditorium 101
UC Santa Cruz
UC Santa Cruz sponsors:
CIRM Stem Cell Training Program
Molecular, Cell, and Developmental Biology Department
Stevenson College
Philosophy Department
Center for Biomolecular Science & Engineering
California Institute for Quantitative Biomedical Research (QB3)
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