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The Nanopore Project

Technical description: Nanopore analysis of DNA molecules

Project members

 
   
 
 
   
  Nanopore sensors for nucleic acid analysis.
Nakane JJ, Akeson M, Marziali A. J Phys Condensed Matter. 2003 Aug 20; 15(32):R1365-93.

Highly accurate classification of Watson-Crick basepairs on termini of single DNA molecules.
Winters-Hilt S, Vercoutere W, DeGuzman VS, Deamer D, Akeson M, Haussler D. Biophys J. 2003 Feb; 84(2 pt 1):967-76.

Discrimination among individual Watson-Crick base pairs at the termini of single DNA hairpin molecules. Vercoutere WA, Winters-Hilt S, DeGuzman VS, Deamer D, Ridino SE, Rodgers JT, Olsen HE, Marziali A, Akeson M. Nucleic Acids Res. 2003 Feb 15; 31(4):1311-8.

Biosensors for DNA sequence detection.
Vercoutere W, Akeson M. Curr Opin Chem Biol. 2002 Dec; 6(6):816-22.

Characterization of nucleic acids by nanopore analysis.
Deamer DW, Branton D. Acc Chem Res. 2002 Oct; 35(10):817-25.

Evaluation of nanopores as candidates for electronic analyte detection
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Nakane J, Akeson M, Marziali A. Electrophoresis. 2002 Aug; 23(16):2592-601.

Use of a nanoscale pore to read short segments within single polynucleotide molecules.
Akeson M, Deamer DW, Vercoutere W, Braslau R, Olsen H. In: Structure and Dynamics of Confined Polymers, J Kasianowicz, M Kellermayer, D Deamer (eds). Bikal, Hungary, 2002, pp. 187-200.

Mechanism of ionic current blockades during polymer transport through pores of nanometer dimensions. Deamer DW, Olsen H, Akeson MA, Kasianowicz J. In: Structure and Dynamics of Confined Polymers, J Kasianowicz, M Kellermayer, D Deamer (eds). Bikal, Hungary, 2002, pp.165-176.

Rapid discrimination among individual DNA hairpin molecules at single nucleotide resolution using an ion channel. Vercoutere W, Winters-Hilt S, Olsen H, Deamer D, Haussler D, Akeson M. Nat Biotechnol. 2001 Mar; 19(3):248-52.

New DNA sequencing methods
.
Marziali A, Akeson M. Annu Rev Biomed Eng. 2001; 3:195-223.

Nanopores and nucleic acids: prospects for ultrarapid sequencing.
Deamer DW, Akeson M. Trends Biotechnol 2000 Apr; 18(4):147-51.

Water transport by the bacterial channel alpha-hemolysin.
Paula S, Akeson M, Deamer D. Biochim BiophysActa. 1999 Apr 14; 1418(1): 117-26.

Microsecond time-scale discrimination among polycytidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers or as segments within single RNA molecules
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Akeson M, Branton D, Kasianowicz JJ, Brandin E, Deamer DW. Biophys J. 1999 Dec; 77(6):3227-33.
   
 
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