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Exploring the basic biological systems operating in the processes of self-renewal and differentiation of stem cells
The research takes several approaches: studies in key model organisms, such as the mouse, fruit fly, and worm, using genetics and molecular biology; computational approaches for understanding gene regulatory networks, expression patterns, and alternative splicing; and bioinformatics approaches that integrate and display all large-scale data sets collected from stem cell research.
Individual projects focus on a number of biological systems, including germ line and nervous system development, epigenetic mechanisms of gene regulation, blood cell differentiation, mammalian embryonic cell fates, wound healing, and the immune system.
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