Developing and applying experimental and computational approaches to elucidate molecular structure, design novel molecules, and study complex biological processes

REPRESENTATIVE PROJECTS

SAM Sequence Alignment and Modeling System

Ribosome Project

Remarkable Protein Structures... and Where They Go Wrong in Disease

Natural and Man-made Therapies from the Laboratory

Small Molecule Modulators Of The Actin Cytoskeleton: A Chemical Genetics Approach

RESEARCH STORIES

Discovery of gene for black coat color in dogs has broad implications

RNA enzyme structure offers a glimpse into the origins of life

UCSC programming prowess gets kudos for protein structure prediction

Atomic-resolution structure of a ribozyme yields insights into RNA catalysis and the origins of life

Nerve verve: laser-assisted nanosurgery to study nerve regeneration in the roundworm C. elegans

An unusual RNA structure in the SARS virus offers a promising target for antiviral drugs

Antibiotic rifampin shows promise for fighting Parkinson's disease

Researchers find clues to the normal function of prion proteins

New images reveal the workings of cellular protein factories

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UCSC FACILITIES

Electron Spin Resonance Facility

Macromolecular X-Ray Crystallography Facility

Microscopy & Imaging Facility

Nanosecond Time-Resolved Laser Spectroscopy Laboratory

Nuclear Magnetic Resonance Facility

Proteomics Facility

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